Anthocyanins, anthocyanin derivatives, and colorectal cancer

Li Shu Wang, Chieh Ti Kuo, Dan Peiffer, Claire Seguin, Kristen Stoner, Yi Wen Huang, Tim H.M. Huang, Nita Salzman, Zhongfa Liu, Daniel Rosenberg, Guang Yu Yang, Wencai Yang, Xiuli Bi, Steven Carmella, Stephen Hecht, Gary Stoner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Anthocyanins are a ubiquitous group of water-soluble plant metabolites of the flavonoid family. They are “nature’s colors,” responsible for the blue, purple, red, and intermediate colors of leaves, flowers, vegetables, and fruits, especially berries. The daily intake of anthocyanins in the U.S. diet is estimated to be as much as 180–215 mg, or about ninefold higher than that of other flavonoids such as quercetin, genistein, and apigenin [1]. Epidemiological studies suggest that the consumption of anthocyanins lowers the risk for diabetes, arthritis, cardiovascular disease, and cancer due, at least in part, to their anti-inflammatory and antioxidant activities [2]. The chemistry, bioavailability, and chemopreventive effects of anthocyanins in multiple tissues have been summarized in our earlier publication [3] and will not be addressed here. This chapter focuses exclusively on mechanistic studies of the prevention of colorectal cancer with anthocyanins, including results from in vitro cell culture systems, in vivo animal model systems, and human studies. In addition, recent studies from our laboratory and those of our collaborators of the effects of anthocyanins on inflammation-associated colorectal cancer, that is ulcerative colitis, are discussed. Finally, this chapter summarizes the known chemopreventive effects of protocatechuic acid (PCA), a major metabolite of anthocyanins. Additional in vitro and in vivo studies of the potential preventative effects of PCA in animal model and human systems are recommended.

Original languageEnglish (US)
Title of host publicationAnthocyanins in Health and Disease
PublisherCRC Press
Pages225-243
Number of pages19
ISBN (Electronic)9781439894767
ISBN (Print)9781439894712
DOIs
StatePublished - Jan 1 2013

Fingerprint Dive into the research topics of 'Anthocyanins, anthocyanin derivatives, and colorectal cancer'. Together they form a unique fingerprint.

  • Cite this

    Wang, L. S., Kuo, C. T., Peiffer, D., Seguin, C., Stoner, K., Huang, Y. W., Huang, T. H. M., Salzman, N., Liu, Z., Rosenberg, D., Yang, G. Y., Yang, W., Bi, X., Carmella, S., Hecht, S., & Stoner, G. (2013). Anthocyanins, anthocyanin derivatives, and colorectal cancer. In Anthocyanins in Health and Disease (pp. 225-243). CRC Press. https://doi.org/10.1201/b15554