Anterior hippocampal volume reduction in male patients with schizophrenia

Mary P. Pegues, Linda J. Rogers, Diane Amend, Sophia Vinogradov, Raymond F. Deicken

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Quantitative high resolution magnetic resonance imaging (MRI) was utilized to measure anterior, posterior, and total hippocampal volumes in 27 male patients with chronic schizophrenia and 24 male controls. To optimize measurement techniques, hippocampal volumes were: (1) acquired with 1.4-mm slices; (2) excluded with the amygdala; (3) normalized for position; and (4) corrected for total intracranial volume (ICV). The results of a linear mixed effects regression analysis, which made it possible to analyze total anterior and total posterior hippocampal volumes separately, indicated that the anterior hippocampus was significantly smaller in the schizophrenic group relative to the control group. There were no significant group differences with respect to posterior hippocampal volumes, and no significant correlations between hippocampal volumes and illness duration. A significant lateralized asymmetry was also noted in both groups with the right hippocampal volume being larger than the left. These preliminary findings support a significant anterior hippocampal volume reduction in men with schizophrenia as well as a similar hippocampal volume asymmetry in both male controls and schizophrenics.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalSchizophrenia Research
Issue number2-3
StatePublished - Apr 1 2003

Bibliographical note

Funding Information:
This research was supported by a 1997 Stanley Foundation Research Award (RFD) and National Institutes of Mental Health Grant MH58244 to Dr. Deicken.


  • Brain
  • Hippocampus
  • Limbic system
  • Magnetic resonance imaging
  • Schizophrenia


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