Anterior Corpus Callosotomy Using Laser Interstitial Thermal Therapy for Refractory Epilepsy

Tyler Ball, Mayur Sharma, Andrew C. White, Joseph S. Neimat

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Corpus callosotomy is a viable treatment for patients with refractory generalized or multifocal epilepsy, particularly those who have drop attacks. Laser interstitial thermal therapy (LITT) is a minimally invasive surgical option for various intracranial lesions. In this report, we present a 2-Trajectory thermal ablation using the NeuroBlate® system (Monteris Medical, MN, USA) for an anterior two-Thirds callosotomy in a patient with refractory epilepsy and frequent drop attacks. Adequate ablation of the corpus callosum was confirmed by MRI during the procedure. At the 1-month follow-up, the frequency had decreased from multiple seizures per day to only 3 over the course of 1 month. In addition, he had not suffered any drop attacks or tonic-clonic movements since the procedure. Five months after surgery, seizures had decreased to 1 per month with no drop attacks or loss of consciousness, consistent with an Engel class II outcome. In conclusion, LITT ablation of the corpus callosum is a safe, feasible, and minimally invasive treatment option for patients with refractory epilepsy, and it may be an attractive alternative for patients unwilling or unable to undergo open surgery.

Original languageEnglish (US)
Pages (from-to)406-411
Number of pages6
JournalStereotactic and Functional Neurosurgery
Issue number6
StatePublished - Feb 1 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 S. Karger AG, Basel.


  • Corpus callosotomy
  • Drop attacks
  • Epilepsy
  • Laser interstitial thermal therapy
  • Minimally invasive callosotomy


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