Anterior cingulate and cerebellar GABA and Glu correlations measured by 1H J-difference spectroscopy

Kevin W. Waddell, Parham Zanjanipour, Subechhya Pradhan, Lei Xu, Edward B. Welch, James M. Joers, Peter R. Martin, Malcolm J. Avison, John C. Gore

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Gamma-aminobutyric acid (GABA) and glutamate (Glu) levels, normalized to total creatine (tCr), were measured in the anterior cingulate and cerebellar vermis in healthy adults (n=19, age=24.6±6.4 years) using 1H MRS at 3 T, and metabolite correlations across regions and subjects were determined. Mean anterior cingulate and cerebellar GABA/tCr ratios were 0.31 (0.08) and 0.23 (0.06), respectively, while corresponding Glu levels were 1.16 (0.10) and 0.70 (0.07), respectively. Anterior cingulate and cerebellar glutamate levels were correlated (r=0.6103, P=0140), although it is noted that when adjusted for multiple comparisons, all correlations reported here cluster to a P value of .0583. It is unlikely that this correlation is driven by correlations in tCr, since interregional correlations were not observed for other metabolites referenced to tCr. Correlations were also observed among metabolites in both the anterior cingulate and cerebellar vermis. In the former, N-acetylasparate was linearly dependent on glutamate (r=0.6577, P=0063) and, at or below this significance threshold, four metabolites were correlated in the cerebellar vermis (Ins/tCh: r=0.6261, P=0109. NAA/tCh: r=0.6426, P=0082. NAA/Glu: r=0.6412, P=0085. tCh/Glu: r=0.6193, P=0.0122).

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalMagnetic Resonance Imaging
Issue number1
StatePublished - Jan 2011

Bibliographical note

Funding Information:
This work was supported by an NIH training grant 5T32 EB001628 entitled “Postdoctoral Training in Biomedical MRI and MRS” and an NIH Biomedical Research Partnership grant EB0000461 .


  • Anterior cingulated
  • Cerebellar vermis
  • GABA
  • Gamma-aminobutyric acid
  • Glutamate
  • J-Difference
  • MRS
  • Metabolite correlations


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