Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats

Yunn Hwa Ma, Earl W. Dunham

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The hemodynamic effects of platelet activating factor (PAF), PAF antagonist and a precursor of PAF, 1-palmityl-2-acetyl-glycerol (PAG), were examined in pentobarbital-anesthetized spontaneously hypertensive rats to determine whether functionally significant amounts of PAF are produced via the cholinephosphotransferase pathway of PAF synthesis in vivo. Intravenous bolus doses of PAF, PAG and nitroprusside elicited hypotension and active mesenteric vasodilatation. Responses to PAG were slower in onset and longer in duration than those of PAF and nitroprusside. The specific PAF antagonists, CV-3988 and SRI 63-675, attenuated PAG- and PAF-, but not nitroprusside-induced changes in blood pressure and mesenteric flow/resistance. In contrast, captopril, which blocked the effects of angiotensin I, did not influence the hypotension caused by PAG, PAF and nitroprusside. The results suggest that the vasodilator effects of PAG are attributable to PAF produced from this alkylacetylglycerol, and the renin-angiotensin system does not appear to influence the biotransformation of PAG of PAF or the hypotensive action of PAF.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalEuropean Journal of Pharmacology
Volume145
Issue number2
DOIs
StatePublished - Jan 12 1988

Keywords

  • Captopril
  • Cholinephosphotransferase
  • Hypotension
  • Palmitylacetylglycerol
  • Platelet activating factor
  • Vasodilators

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