Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators

Rita B. Messing, Philip S. Portoghese, Akira E. Takemori, Sheldon B. Sparber

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Experiments were conducted to test the in vivo opiate specificity and long-lasting effects of two non-equilibrium opiate antagonists: β-chlornaltrexamine (β-CNA) and the β-fumarate methyl ester derivative of naltrexone (β-FNA). β-CNA (2.5 or 5.0 μg, ICV) partially antagonized suppression of conditioned autoshaped behavior by morphine, when morphine was administered 48-72 hr after β-CNA. β-CNA had no effect on amphetamine-induced suppression of autoshaped responding, nor did it antagonized the suppression in rearing activity induced by either morphine or amphetamine. Similarly, β-FNA (5 mg/kg, IP) antagonized the suppression of conditioned behavior by morphine, for up to 48 hr, while having no effect on amphetamine-induced suppression of autoshaped responding, or on the suppression of rearing activity induced by morphine or amphetamine. Further peripherally administered β-FNA acts in the brain, since it antagonized analgesia following ICV morphine administration.

Original languageEnglish (US)
Pages (from-to)621-626
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number4
DOIs
StatePublished - Apr 1982

Keywords

  • Amphetamine
  • Autoshaped behavior
  • Morphine
  • Opiate receptor alkylators

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