Abstract
Chlornaltrexamine (β-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermic tolerance and physical dependence produced by Δ9-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.
Original language | English (US) |
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Pages (from-to) | 219-224 |
Number of pages | 6 |
Journal | European Journal of Pharmacology |
Volume | 70 |
Issue number | 2 |
DOIs | |
State | Published - Mar 12 1981 |
Keywords
- Analgesia
- Chlornaltrexamine
- Dependence
- Hypothermia
- Morphine
- THC
- Tolerance
- Δ-Tetrahydrocannabinol
- β-CNA