Ankyrins and cellular targeting of diverse membrane proteins to physiological sites

V. Bennett, Lihsia Chen

Research output: Contribution to journalReview article

137 Scopus citations

Abstract

Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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