Ankle dorsiflexor twitch properties in malignant hyperthermia

John G. Quinlan, Paul A Iaizzo, Edward H. Lambert, Gerald A. Gronert

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A noninvasive method to diagnose malignant hyperthermia (MH) was sought. To this end, in vivo isometric twitch properties of the ankle dorsi‐flexor muscles were studied in three groups: (1) MH‐susceptible patients (n = 12), (2) relatives (n = 12) of MH‐susceptible patients who were judged to be MH resistant, and (3) a group of normal volunteers (n = 42) chosen from the community. Twitch properties were studied under resting state conditions and with 1 or 2 Hz stimulation to produce the negative staircase twitch response. There was a high degree of overlap between the ranges of the measured twitch parameters of all groups. Thus, the techniques presented in this study have no value in diagnosing susceptibility to MH. Several physiological features of human isometric twitch properties were demonstrated: (1) slowing of twitch speed with advancing age, (2) strong positive correlation between body weight and twitch torque, and (3) a negative staircase response typical of that described in other mammalian twitch studies.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalMuscle & Nerve
Issue number2
StatePublished - Feb 1989
Externally publishedYes


  • excitation contraction coupling
  • human
  • malignant hyperthermia
  • skeletal muscle
  • staircase
  • twitch


Dive into the research topics of 'Ankle dorsiflexor twitch properties in malignant hyperthermia'. Together they form a unique fingerprint.

Cite this