Ankle-brachial index and hemostatic markers in the atherosclerosis Risk in Communities (ARIC) study cohort

Laura M. Reich, Gerardo Heiss, Lori L. Boland, Alan T. Hirsch, Kenneth Wu, Aaron R. Folsom

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

To determine whether elevated levels of hemostatic and inflammatory markers [von Willebrand factor (vWF), fibrinogen, D-dimer, factor VII, factor VIII, PAI-1, tPA, beta-thromboglobulin (β-TG), CRP, and WBC count] are associated with increased peripheral arterial disease (PAD) prevalence, measured by low ABI, we studied 13,778 participants from the ARIC study in a cross-sectional analysis after adjustment for major cardiovascular risk factors. PAD was positively associated with fibrinogen, vWF, factor VIII, WBC count, D-dimer, β-TG, and CRP (p for trend <0.05) but not with the other markers. Adjusted odds ratios for the highest versus the lowest quartile of fibrinogen in men and women, respectively, were 3.49 (95% CI 1.68-7.26) and 2.44 (95% CI 1.58-3.77); for vWF 2.36 (95% CI 1.36-4.07) and 1.45 (95% CI 1.00-2.10); for factor VIII 2.31 (95% CI 1.36-3.94) and 1.68 (95% CI 1.14-2.48). In a smaller subset, the sex and risk factor adjusted odds ratio for the highest versus the lowest quartile of D-dimer was 2.70 (95% CI 1.56-4.65), for β-TG was 1.80 (95% CI 1.12-2.88), and for CRP was 1.57 (95% CI 0.84-2.95). Plasma levels of hemostatic and inflammatory markers are elevated in PAD, suggesting these processes are involved in the pathophysiology of PAD.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalVascular Medicine
Volume12
Issue number4
DOIs
StatePublished - Dec 1 2007

Keywords

  • Atherosclerosis
  • Blood coagulation factors
  • Hemostasis
  • Peripheral vascular disease

Fingerprint Dive into the research topics of 'Ankle-brachial index and hemostatic markers in the atherosclerosis Risk in Communities (ARIC) study cohort'. Together they form a unique fingerprint.

  • Cite this