TY - JOUR
T1 - Anisodamine Inhibits Thromboxane Synthesis, Granulocyte Aggregation, and Platelet Aggregation
T2 - A Possible Mechanism for Its Efficacy in Bacteremic Shock
AU - Rui Juan, Xiu
AU - Coppo, Patricia A.
AU - Jacob, Harry S.
PY - 1982/3/12
Y1 - 1982/3/12
N2 - Anisodamine hydrochloride is a vasoactive drug produced in the People's Republic of China that appears efficacious in clinical and experimental bacteremic shock, and about whose mode of action little is known. Suspecting that the drug might work by inhibition of platelet or granulocyte aggregation, or both, we tested it in these systems. Anisodamine proved a modest inhibitor of granulocyte aggregation and a powerful inhibitor of platelet aggregation; thromboxane synthesis was inhibited in anisodaminetreated platelets, further suggesting that the biochemical mode of action might be inhibition of cyclo-oxygenase or thromboxane synthetase. (JAMA 1982;247:1458-1460).
AB - Anisodamine hydrochloride is a vasoactive drug produced in the People's Republic of China that appears efficacious in clinical and experimental bacteremic shock, and about whose mode of action little is known. Suspecting that the drug might work by inhibition of platelet or granulocyte aggregation, or both, we tested it in these systems. Anisodamine proved a modest inhibitor of granulocyte aggregation and a powerful inhibitor of platelet aggregation; thromboxane synthesis was inhibited in anisodaminetreated platelets, further suggesting that the biochemical mode of action might be inhibition of cyclo-oxygenase or thromboxane synthetase. (JAMA 1982;247:1458-1460).
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U2 - 10.1001/jama.1982.03320350062033
DO - 10.1001/jama.1982.03320350062033
M3 - Article
C2 - 7057538
AN - SCOPUS:0020039728
SN - 0098-7484
VL - 247
SP - 1458
EP - 1460
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 10
ER -