Animal models of PD: Pieces of the same puzzle?

Ted M. Dawson, Allen S. Mandir, Michael K. Lee

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in older models are yielding important new information about the pathogenesis of PD. This has prompted us to critically review the current animal models for PD and discuss how these models may yield fresh insights into the pathogenesis of PD, as well as new therapeutic opportunities.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
Issue number2
StatePublished - Jul 18 2002


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