Animal models of naturally occurring stone disease

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15 Scopus citations


The prevalence of urolithiasis in humans is increasing worldwide; however, non-surgical treatment and prevention options remain limited despite decades of investigation. Most existing laboratory animal models for urolithiasis rely on highly artificial methods of stone induction and, as a result, might not be fully applicable to the study of natural stone initiation and growth. Animal models that naturally and spontaneously form uroliths are an underused resource in the study of human stone disease and offer many potential opportunities for improving insight into stone pathogenesis. These models include domestic dogs and cats, as well as a variety of other captive and wild species, such as otters, dolphins and ferrets, that form calcium oxalate, struvite, uric acid, cystine and other stone types. Improved collaboration between urologists, basic scientists and veterinarians is warranted to further our understanding of how stones form and to consider possible new preventive and therapeutic treatment options.

Original languageEnglish (US)
Pages (from-to)691-705
Number of pages15
JournalNature Reviews Urology
Issue number12
StatePublished - Dec 2020

Bibliographical note

Funding Information:
Partial support for E.F. was provided by the Office of the Director, National Institutes of Health (NIH) under award number K01-OD019912.

Publisher Copyright:
© 2020, Springer Nature Limited.


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