TY - JOUR
T1 - Animal models of breast cancer
T2 - Experimental design and their use in nutrition and psychosocial research
AU - Clarke, Robert
PY - 1997
Y1 - 1997
N2 - This is the second Special Issue addressing the diversity and use of animal models of breast cancer. The previous issue, dealt with a variety of topics such as the characteristics of chemically- and virally-induced rodent models, immunobiologies of immunedeficient mice, transgenic mouse models, and models of metastasis. In the first part of this second Special Issue, the articles address animal models for studying life-style factors, including psychosocial, exercise, and nutritional research in breast cancer. In the second section, there is emphasis on the controversial area of dietary fat, with other authors addressing caloric restriction and dietary isoflavonoids, retinoids, and monoterpenes in the third part. In the final section, a series of authors provide suggestions for approaching various issues involving experimental design, including nutritional studies, drug screening models, statistical considerations, quantitation of tumor growth kinetics, and animal husbandry. These articles, and some additional issues raised during the previous Special Issue, are briefly discussed in this overview. They include a further evaluation of the relative merits of 7,12-dimethylbenz(a)anthracene and N-nitroso-N-methylurea as carcinogens, and of the use of the AIN76 and AIN93 semipurified diets in studies of mammary carcinogenesis.
AB - This is the second Special Issue addressing the diversity and use of animal models of breast cancer. The previous issue, dealt with a variety of topics such as the characteristics of chemically- and virally-induced rodent models, immunobiologies of immunedeficient mice, transgenic mouse models, and models of metastasis. In the first part of this second Special Issue, the articles address animal models for studying life-style factors, including psychosocial, exercise, and nutritional research in breast cancer. In the second section, there is emphasis on the controversial area of dietary fat, with other authors addressing caloric restriction and dietary isoflavonoids, retinoids, and monoterpenes in the third part. In the final section, a series of authors provide suggestions for approaching various issues involving experimental design, including nutritional studies, drug screening models, statistical considerations, quantitation of tumor growth kinetics, and animal husbandry. These articles, and some additional issues raised during the previous Special Issue, are briefly discussed in this overview. They include a further evaluation of the relative merits of 7,12-dimethylbenz(a)anthracene and N-nitroso-N-methylurea as carcinogens, and of the use of the AIN76 and AIN93 semipurified diets in studies of mammary carcinogenesis.
KW - AIN76
KW - AIN93
KW - Animal models
KW - Breast cancer
KW - Cell lines
KW - DMBA
KW - NMU
UR - http://www.scopus.com/inward/record.url?scp=0031457952&partnerID=8YFLogxK
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U2 - 10.1023/A:1005916627972
DO - 10.1023/A:1005916627972
M3 - Review article
C2 - 9478268
AN - SCOPUS:0031457952
SN - 0167-6806
VL - 46
SP - 117
EP - 133
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 2-3
ER -