Animal models for cardiac research

Nicholas A Robinson, Laura Souslian, Robert P. Gallegos, Andrew L. Rivard, Agustin P Dalmasso, Richard W Bianco

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

The modern era of cardiac surgery is largely considered to have begun in the animal research laboratories. Today, animal models continue to be used for the study of cardiovascular diseases and are required for the preclinical assessment of pharmaceuticals, mechanical devices, therapeutic procedures, and/or continuation therapies. This chapter was written to provide readers and potential investigators with important background information necessary for the process of matching an experimental hypothesis to an animal species that will serve as an appropriate model for studying a specific cardiovascular disease or for testing a given medical device. A review of the current animal models used in cardiac research is provided and arranged by disease state. Critical factors to consider when choosing an appropriate animal model including costs, reproducibility, and degree of similarity of the model to human disease are discussed. Thus, this chapter can be utilized as a practical guide for planning of research protocols.

Original languageEnglish (US)
Title of host publicationHandbook of Cardiac Anatomy, Physiology, and Devices, Third Edition
PublisherSpringer International Publishing
Pages469-491
Number of pages23
ISBN (Electronic)9783319194646
ISBN (Print)9783319194639
DOIs
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2015.

Keywords

  • Animal model
  • Atrial fibrillation
  • Cardiomyoplasty
  • Heart failure
  • Heart transplantation
  • Isolated cardiomyocytes
  • Isolated perfused heart
  • Mechanical device testing
  • Myocardial ischemia
  • Stem cell research
  • Valve disease

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