Animal models for cardiac research

Richard W. Bianco, Robert P. Gallegos, Andrew L. Rivard, Jessica Voight, Agustin P. Dalmasso

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The modern era of cardiac surgery is largely considered to have begun in the animal research laboratories. Today, animal models continue to be used for the study of cardiovascular diseases and are required for the preclinical assessment of pharmaceuticals, mechanical devices, therapeutic procedures, and/or continuation therapies. This chapter was designed to provide readers and potential investigators with important background information necessary for the process of matching an experimental hypothesis to an animal species that will serve as an appropriate model for studying a specific cardiovascular disease or for testing a given medical device. A review of the current animal models used in cardiac research is provided and arranged by disease state. Critical factors to consider when choosing an appropriate animal model including cost, reproducibility, and degree of similarity of the model to human disease are discussed. Thus, this chapter can be utilized as a practical guide for planning of research protocols.

Original languageEnglish (US)
Title of host publicationHandbook of Cardiac Anatomy, Physiology, and Devices
Subtitle of host publicationSecond Edition
PublisherHumana Press
Pages393-410
Number of pages18
ISBN (Print)9781588294432
DOIs
StatePublished - Dec 1 2005

Keywords

  • Animal model
  • Atrial fibrillation
  • Cardiomyoplasty
  • Heart failure
  • Heart transplantation
  • Isolated cardiomyocytes
  • Isolated perfused heart
  • Mechanical device testing
  • Myocardial ischemia
  • Stem cell research
  • Valve disease

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