Animal cell bioreactors — recent advances and challenges to scale‐up

Wei-Shou Hu, Madhusudan V. Peshwa

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


The demand for animal cell derived products has stimulated the development of bioreactors in the last decade. Most of those developments allow a higher cell concentration to be achieved in the bioreactor than in the past, primarily by means of the continuous flow of culture medium and a mechanism of cell retention. The advantages and technological challenges of some of these developments are discussed. Lagging behind the bioreactor developments is the strategy for culture operation and optimization. The need for suitable kinetic models to describe animal cell growth is emphasized.

Original languageEnglish (US)
Pages (from-to)409-420
Number of pages12
JournalThe Canadian Journal of Chemical Engineering
Issue number2
StatePublished - Apr 1991


  • animal cell culture
  • bioreactor
  • scale‐up


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