Angiotensins promote fluid absorption in the rat ileum after their CNS administration

David R Brown, Michael A. Gillespie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Angiotensin II (A-II) has been found previously to increase mean arterial pressure (MAP) and enhance fluid absorption in the rat ileum in situ after intracerebroventricular (ICV) administration. In this investigation, the CNS-mediated proabsorptive actions of A-II and other products of the renin-angiotensin system, as well as nonhomologous peptides were further characterized in the urethane-anesthetized rat. At an ICV bolus dose of 1 μg, angiotensinogen, A-I, A-II and A-III produced significant elevations in MAP, but only A-II and A-III increased ileal absorption significantly above that of saline-treated rats. The ICV administration of other unrelated peptides did not mimic the actions of A-II or A-III. The results suggest that the pressor and ileal proabsorptive actions of angiotensins are mediated through different CNS mechanisms and that these peptides uniquely alter intestinal transport.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalPeptides
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1989

Keywords

  • Absorption
  • Angiotensin
  • Blood pressure
  • CNS
  • Ileum
  • Jejunum
  • Renin
  • Somatostatin
  • TRH

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