Abstract
Plasma renin activity frequently is increased in patients with congestive heart failure. This increase in inversely related to serum sodium concentration, but is not correlated with hemodynamic measurements. Nonetheless, inhibition of converting enzyme activity by administration of teprotide or captopril results in a decrease in systemic vascular resistance that is directly related to the control plasma renin activity. These data suggest that angiotensin II contributes to the systemic vasoconstriction of heart failure and that chronic inhibition of the renin-angiotensin system may have a salutary effect on left ventricular performance in patients with heart failure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1480-1483 |
| Number of pages | 4 |
| Journal | The American Journal of Cardiology |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| State | Published - Apr 21 1982 |
Bibliographical note
Funding Information:From the Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota. This study was supported in part by Grant HL-22977 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Address for reprints: Jay N. Cohn, MD, Box 488, University of Minnesota Hospital, Minneapolis, Minnesota 55455.