Angiotensin-converting enzyme inhibition in congestive heart failure: The concept

Jay N Cohn, T. Barry Levine

Research output: Contribution to journalArticle

31 Scopus citations


Plasma renin activity frequently is increased in patients with congestive heart failure. This increase in inversely related to serum sodium concentration, but is not correlated with hemodynamic measurements. Nonetheless, inhibition of converting enzyme activity by administration of teprotide or captopril results in a decrease in systemic vascular resistance that is directly related to the control plasma renin activity. These data suggest that angiotensin II contributes to the systemic vasoconstriction of heart failure and that chronic inhibition of the renin-angiotensin system may have a salutary effect on left ventricular performance in patients with heart failure.

Original languageEnglish (US)
Pages (from-to)1480-1483
Number of pages4
JournalThe American Journal of Cardiology
Issue number6
StatePublished - Apr 21 1982

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