Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane

Annemiek W. Nap, Gerard A.J. Dunselman, Arjan W. Griffioen, Kevin H Mayo, Johannes L.H. Evers, Patrick G. Groothuis

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.

Original languageEnglish (US)
Pages (from-to)793-795
Number of pages3
JournalFertility and Sterility
Volume83
Issue number3
DOIs
StatePublished - Mar 2005

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