Angiogenic growth factors: Their effects and potential in soft tissue wound healing

David B. Hom, Robert H. Maisel

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Since their discovery 30 years ago, angiogenic growth factors have been demonstrated to stimulate neovascularization in vitro and in animal studies. Over the last decade, knowledge gained in the field of angiogenic growth factors has grown immensely. These angiogenic growth factors exist in four major families: fibroblast growth factor (FGF), transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF). Each has the ability to induce soft tissue vascularization in microgram quantities. In animal models, FGF, TGF-β, PDGF, and EGF have been shown to enhance soft tissue wound healing. In human clinical trials, EGF and a mixture of PDGFs have been demonstrated to accelerate epidermal regeneration in cutaneous wounds. These factors have considerable therapeutic potential in the areas of soft tissue wound healing and otolaryngology. This article reviews important aspects of angiogenic growth factors and discusses their future potential in soft tissue wound healing.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalAnnals of Otology, Rhinology & Laryngology
Issue number4
StatePublished - Apr 1992

Bibliographical note

Copyright 2016 Elsevier B.V., All rights reserved.


  • blood vessels
  • growth substances
  • wound healing


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