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Angiogenesis and lymphangiogenesis in primary cutaneous lymphomas: a narrative review

  • Mario Della Mura
  • , Joana Sorino
  • , Gerardo Cazzato
  • , Giuseppe Ingravallo
  • , Alessio Giubellino
  • , Domenico Ribatti

Research output: Contribution to journalReview articlepeer-review

Abstract

Angiogenesis and lymphangiogenesis are hallmarks of cancer and widely investigated both in solid and hematologic malignancies, correlating with tumor aggressiveness and progression. To date, the meaning of angiogenesis in primary cutaneous lymphomas has not been fully clarified, with most data coming from T cell lymphomas, in particular mycosis fungoides. Herein, we provide a comprehensive review about their significance in both primary cutaneous T cell and B cell lymphomas, with the aim to deepen the underlying molecular mechanism and role in tumor development and progression.

Original languageEnglish (US)
Article number343
JournalClinical and Experimental Medicine
Volume25
Issue number1
DOIs
StatePublished - Dec 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Angiogenesis
  • B cell lymphoma
  • Lymphangiogenesis
  • Microvessel density
  • Mycosis fungoides
  • Primary cutaneous lymphoma
  • T cell lymphoma

PubMed: MeSH publication types

  • Journal Article
  • Review

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