Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis

Olga V. Kazanskaya; Elena A. Severtzova; K. Anukampa Barth; Galina V. Ermakova; Sergey A. Lukyanov; Alex O. Benyumov; Maria Pannese; Edoardo Boncinelli; Stephen W. Wilson; Andrey G. Zaraisky

doi:10.1016/S0378-1119(97)00326-0

Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis

Olga V. Kazanskaya, Elena A. Severtzova, K. Anukampa Barth, Galina V. Ermakova, Sergey A. Lukyanov, Alex O. Benyumov, Maria Pannese, Edoardo Boncinelli, Stephen W. Wilson, Andrey G. Zaraisky

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Five novel genes homologous to the homeobox-containing genes Xanf-1 and Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken and human. Comparative analysis of the homeodomain primary structure of these genes revealed that they belong to a novel class of homeobox genes, which we name Anf. All genes of this class investigated so far have similar patterns of expression during early embryogenesis, characterized by maximal transcript levels being present at the anterior extremity of the main embryonic body axis. The data obtained also suggest that, despite considerable high structural divergence between their homeodomains, all known Anf genes may be orthologues, and thus represent one of the most quickly evolving classes of vertebrate homeobox genes.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	Gene
Volume	200
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(97)00326-0
State	Published - Oct 24 1997

Bibliographical note

Funding Information:
We would like to thank Oleg Vasiliev for technical assistance and fruitful discussions. We are also grateful to Anna Stornaiouolo, Antonello Mallamaci and Giovanni Lavorgna and Dominic Delaney for providing expert advice. We thank the Telethon Institute of Genetics and Medicine (TIGEM) for supplying the NT2/D1 library. This work was supported by grants from the Russian Human Genome Project, the Russian Foundation for Fundamental Investigations (95-04-11320a and 97-04-49883), and INTAS (95-IN-RU-1152) and Wellcome Trust funding to S.W. O.V.K. was supported by an EMBO East European fellowship.

Keywords

Embryo
Forebrain patterning
Homeobox genes

Publisher link

10.1016/S0378-1119(97)00326-0

Find It

Find It at U of M Libraries

Cite this

@article{6353a57db7474a91859d07dd8e0ea515,

title = "Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis",

abstract = "Five novel genes homologous to the homeobox-containing genes Xanf-1 and Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken and human. Comparative analysis of the homeodomain primary structure of these genes revealed that they belong to a novel class of homeobox genes, which we name Anf. All genes of this class investigated so far have similar patterns of expression during early embryogenesis, characterized by maximal transcript levels being present at the anterior extremity of the main embryonic body axis. The data obtained also suggest that, despite considerable high structural divergence between their homeodomains, all known Anf genes may be orthologues, and thus represent one of the most quickly evolving classes of vertebrate homeobox genes.",

keywords = "Embryo, Forebrain patterning, Homeobox genes",

author = "Kazanskaya, {Olga V.} and Severtzova, {Elena A.} and Barth, {K. Anukampa} and Ermakova, {Galina V.} and Lukyanov, {Sergey A.} and Benyumov, {Alex O.} and Maria Pannese and Edoardo Boncinelli and Wilson, {Stephen W.} and Zaraisky, {Andrey G.}",

note = "Funding Information: We would like to thank Oleg Vasiliev for technical assistance and fruitful discussions. We are also grateful to Anna Stornaiouolo, Antonello Mallamaci and Giovanni Lavorgna and Dominic Delaney for providing expert advice. We thank the Telethon Institute of Genetics and Medicine (TIGEM) for supplying the NT2/D1 library. This work was supported by grants from the Russian Human Genome Project, the Russian Foundation for Fundamental Investigations (95-04-11320a and 97-04-49883), and INTAS (95-IN-RU-1152) and Wellcome Trust funding to S.W. O.V.K. was supported by an EMBO East European fellowship.",

year = "1997",

month = oct,

day = "24",

doi = "10.1016/S0378-1119(97)00326-0",

language = "English (US)",

volume = "200",

pages = "25--34",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Anf

T2 - A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis

AU - Kazanskaya, Olga V.

AU - Severtzova, Elena A.

AU - Barth, K. Anukampa

AU - Ermakova, Galina V.

AU - Lukyanov, Sergey A.

AU - Benyumov, Alex O.

AU - Pannese, Maria

AU - Boncinelli, Edoardo

AU - Wilson, Stephen W.

AU - Zaraisky, Andrey G.

N1 - Funding Information: We would like to thank Oleg Vasiliev for technical assistance and fruitful discussions. We are also grateful to Anna Stornaiouolo, Antonello Mallamaci and Giovanni Lavorgna and Dominic Delaney for providing expert advice. We thank the Telethon Institute of Genetics and Medicine (TIGEM) for supplying the NT2/D1 library. This work was supported by grants from the Russian Human Genome Project, the Russian Foundation for Fundamental Investigations (95-04-11320a and 97-04-49883), and INTAS (95-IN-RU-1152) and Wellcome Trust funding to S.W. O.V.K. was supported by an EMBO East European fellowship.

PY - 1997/10/24

Y1 - 1997/10/24

N2 - Five novel genes homologous to the homeobox-containing genes Xanf-1 and Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken and human. Comparative analysis of the homeodomain primary structure of these genes revealed that they belong to a novel class of homeobox genes, which we name Anf. All genes of this class investigated so far have similar patterns of expression during early embryogenesis, characterized by maximal transcript levels being present at the anterior extremity of the main embryonic body axis. The data obtained also suggest that, despite considerable high structural divergence between their homeodomains, all known Anf genes may be orthologues, and thus represent one of the most quickly evolving classes of vertebrate homeobox genes.

AB - Five novel genes homologous to the homeobox-containing genes Xanf-1 and Xanf-2 of Xenopus and Hesx-1/Rpx of mouse have been identified as a result of a PCR survey of cDNA in sturgeon, zebrafish, newt, chicken and human. Comparative analysis of the homeodomain primary structure of these genes revealed that they belong to a novel class of homeobox genes, which we name Anf. All genes of this class investigated so far have similar patterns of expression during early embryogenesis, characterized by maximal transcript levels being present at the anterior extremity of the main embryonic body axis. The data obtained also suggest that, despite considerable high structural divergence between their homeodomains, all known Anf genes may be orthologues, and thus represent one of the most quickly evolving classes of vertebrate homeobox genes.

KW - Embryo

KW - Forebrain patterning

KW - Homeobox genes

UR - http://www.scopus.com/inward/record.url?scp=0030778534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030778534&partnerID=8YFLogxK

U2 - 10.1016/S0378-1119(97)00326-0

DO - 10.1016/S0378-1119(97)00326-0

M3 - Article

C2 - 9373136

AN - SCOPUS:0030778534

SN - 0378-1119

VL - 200

SP - 25

EP - 34

JO - Gene

JF - Gene

IS - 1-2

ER -

Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this