TY - JOUR
T1 - Ancylostoma ceylanicum hookworm in myanmar refugees, Thailand, 2012–2015
AU - O’Connell, Elise M.
AU - Mitchell, Tarissa
AU - Papaiakovou, Marina
AU - Pilotte, Nils
AU - Lee, Deborah
AU - Weinberg, Michelle
AU - Sakulrak, Potsawin
AU - Tongsukh, Dilok
AU - Oduro-Boateng, Georgiette
AU - Harrison, Sarah
AU - Williams, Steven A.
AU - Stauffer III, William M
AU - Nutman, Thomas B.
N1 - Publisher Copyright:
© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - During 2012–2015, US-bound refugees living in Myanmar–Thailand border camps (n = 1,839) were surveyed for hookworm infection and treatment response by using quantitative PCR. Samples were collected at 3 time points: after each of 2 treatments with albendazole and after resettlement in the United States. Baseline prevalence of Necator americanus hookworm was 25.4%, Ancylostoma duodenale 0%, and Ancylostoma ceylanicum (a zoonosis) 5.4%. Compared with N. americanus prevalence, A. ceylanicum hookworm prevalence peaked in younger age groups, and blood eosinophil concentrations during A. ceylanicum infection were higher than those for N. americanus infection. Female sex was associated with a lower risk for either hookworm infection. Cure rates after 1 dose of albendazole were greater for A. ceylanicum (93.3%) than N. americanus (65.9%) hookworm (p<0.001). Lower N. americanus hookworm cure rates were unrelated to β-tubulin single-nucleotide polymorphisms at codons 200 or 167. A. ceylanicum hookworm infection might be more common in humans than previously recognized.
AB - During 2012–2015, US-bound refugees living in Myanmar–Thailand border camps (n = 1,839) were surveyed for hookworm infection and treatment response by using quantitative PCR. Samples were collected at 3 time points: after each of 2 treatments with albendazole and after resettlement in the United States. Baseline prevalence of Necator americanus hookworm was 25.4%, Ancylostoma duodenale 0%, and Ancylostoma ceylanicum (a zoonosis) 5.4%. Compared with N. americanus prevalence, A. ceylanicum hookworm prevalence peaked in younger age groups, and blood eosinophil concentrations during A. ceylanicum infection were higher than those for N. americanus infection. Female sex was associated with a lower risk for either hookworm infection. Cure rates after 1 dose of albendazole were greater for A. ceylanicum (93.3%) than N. americanus (65.9%) hookworm (p<0.001). Lower N. americanus hookworm cure rates were unrelated to β-tubulin single-nucleotide polymorphisms at codons 200 or 167. A. ceylanicum hookworm infection might be more common in humans than previously recognized.
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U2 - 10.3201/eid2408.180280
DO - 10.3201/eid2408.180280
M3 - Article
C2 - 30014834
AN - SCOPUS:85050373164
SN - 1080-6040
VL - 24
SP - 1472
EP - 1481
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 8
ER -