Anatomical details affect electric field predictions for non-invasive brain stimulation in non-human primates

Kathleen E. Mantell, Nipun D. Perera, Sina Shirinpour, Oula Puonti, Ting Xu, Jan Zimmermann, Arnaud Falchier, Sarah R. Heilbronner, Axel Thielscher, Alexander Opitz

Research output: Contribution to journalArticlepeer-review


Non-human primates (NHPs) have become key for translational research in noninvasive brain stimulation (NIBS). However, in order to create comparable stimulation conditions for humans it is vital to study the accuracy of current modeling practices across species. Numerical models to simulate electric fields are an important tool for experimental planning in NHPs and translation to human studies. It is thus essential whether and to what extent the anatomical details of NHP models agree with current modeling practices when calculating NIBS electric fields. Here, we create highly accurate head models of two non-human primates (NHP) MR data. We evaluate how muscle tissue and head field of view (depending on MRI parameters) affect simulation results in transcranial electric and magnetic stimulation (TES and TMS). Our findings indicate that the inclusion of anisotropic muscle can affect TES electric field strength up to 22% while TMS is largely unaffected. Additionally, comparing a full head model to a cropped head model illustrates the impact of head field of view on electric fields for both TES and TMS. We find opposing effects between TES and TMS with an increase up to 24.8% for TES and a decrease up to 24.6% for TMS for the cropped head model compared to the full head model. Our results provide important insights into the level of anatomical detail needed for NHP head models and can inform future translational efforts for NIBS studies.

Original languageEnglish (US)
Article number120343
StatePublished - Oct 1 2023

Bibliographical note

Funding Information:
Research present here was supported by the University of Minnesota's MnDRIVE Initiative, the National Institute of Health ( RF1MH117428 and RF1MH124909 to AO; R56EB031765 , R01EB031765 , P30DA048742 and P41EB027061 to JZ; R01MH118257 to SRH), and the Lundbeck foundation ( R244–2017–196 and R313–2019–622 to AT; R360–2021–395 to OP).

Publisher Copyright:
© 2023 The Author(s)


  • Finite element method modeling
  • Noninvasive brain stimulation (NIBS)
  • Transcranial electric stimulation (TES), Non-human primate
  • Transcranial magnetic stimulation (TMS)
  • Ultra-high field imaging


Dive into the research topics of 'Anatomical details affect electric field predictions for non-invasive brain stimulation in non-human primates'. Together they form a unique fingerprint.

Cite this