Anatomical Biomarkers for Adolescent Major Depressive Disorder from Diffusion Weighted Imaging using SVM Classifier

Shu Hsien Chu, Christophe Lenglet, Mindy Westlund Schreiner, Bonnie Klimes-Dougan, Kathryn Cullen, Keshab K. Parhi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Adolescent Major Depressive Disorder (MDD) is a common and serious mental illness that could lead to tragic outcomes including chronic adult disability and suicide. In this paper, we explore anatomical features and apply machine learning approaches to identify responsive biomarkers distinguishing MDD patients from healthy subjects. The features of interest include metrics in two categories: a) anatomical connectivity defined by diffusion tensor imaging measurements between a pair of brain regions, and b) topological measurements from anatomical networks. A combination of p-value based filtering and minimum redundancy maximum relevance method is performed to select features for optimal classification accuracy. A leave-one-out cross-validation method is used for the classification performance evaluation. The proposed methodology achieves an improved accuracy of 78%, 90.39% sensitivity, and 79.66% precision for 79 subjects. The most distinguishing features are the betweenness centrality of the right lingual gyrus of the ADC network at 12% sparsity, the participation coefficient of the right lateral occipital sulcus of the ADC network at 22% sparsity, the participation coefficient of the right pars opercularis of the AD network at 16% sparsity, and the participation coefficient of the right lateral orbitofrontal cortex in the ADC network at 10% sparsity. Those network measures reflect the change of connectivity between the regions and their associated anatomical subnetworks.

Original languageEnglish (US)
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2740-2743
Number of pages4
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2018-July
ISSN (Print)1557-170X

Other

Other40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period7/18/187/21/18

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Cite this

Chu, S. H., Lenglet, C., Schreiner, M. W., Klimes-Dougan, B., Cullen, K., & Parhi, K. K. (2018). Anatomical Biomarkers for Adolescent Major Depressive Disorder from Diffusion Weighted Imaging using SVM Classifier. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 2740-2743). [8512852] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8512852