Analysis of the Fenton-Karma model through an approximation by a one-dimensional map

E. G. Tolkacheva, D. G. Schaeffer, D. J. Gauthier, C. C. Mitchell

Research output: Contribution to journalArticle

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The Fenton-Karma model is a simplification of complex ionic models of cardiac membrane that reproduces quantitatively many of the characteristics of heart cells; its behavior is simple enough to be understood analytically. In this paper, a map is derived that approximates the response of the Fenton-Karma model to stimulation in zero spatial dimensions. This map contains some amount of memory, describing the action potential duration as a function of the previous diastolic interval and the previous action potential duration. Results obtained from iteration of the map and numerical simulations of the Fenton-Karma model are in good agreement. In particular, the iterated map admits different types of solutions corresponding to various dynamical behavior of the cardiac cell, such as 1:1 and 2:1 patterns.

Original languageEnglish (US)
Pages (from-to)1034-1042
Number of pages9
Issue number4
StatePublished - Dec 2002


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