Analysis of randomized controlled clinical trials

Robert N. Foley

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


When analyzing the results of a trial, the primary outcome variable must be kept in clear focus. In the analysis plan, consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics; intention-to-treat analysis; interim analyses and stopping rules; mortality comparisons; composite outcomes; research design including run-in periods, factorial, stratified, and crossover designs; number needed to treat; power issues; multivariate modeling; and hypothesis-generating analyses.

Original languageEnglish (US)
Title of host publicationClinical Epidemiology
Subtitle of host publicationPractice and Methods
EditorsPatrick Parfrey, Brendan Barrett
Number of pages14
StatePublished - Dec 1 2009

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Randomized controlled trials
  • analysis
  • intention to treat
  • multivariate modeling
  • research design
  • stopping rules


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