Analysis of organophosphorus insecticides in biological samples by selective ion monitoring gas chromatography-mass spectrometry

Ashok K. Singh; David W. Hewetson; Kathryn C. Jordon; Muhammed Ashraf

doi:10.1016/S0021-9673(00)90100-6

Analysis of organophosphorus insecticides in biological samples by selective ion monitoring gas chromatography-mass spectrometry

Ashok K. Singh, David W. Hewetson, Kathryn C. Jordon, Muhammed Ashraf

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Gas chromatography with chemical ionization or electron impact mass spectrometry and selected ion monitoring provided a simple and sensitive method for measuring organophosphorus insecticides. Chemical ionization produced highermass ions which might increase the selectivity and sensitivity of the assay. The recovery of organophosphates from saline and urine was greater than 75%. The recovery of these compounds from plasma was less than the saline because of the binding of insecticides to plasma protein. Insecticides with lower LD₅₀ values showed lower recovery from plasma than organophosphates with higher LD₅₀ values.

Original language	English (US)
Pages (from-to)	83-96
Number of pages	14
Journal	Journal of Chromatography A
Volume	369
Issue number	C
DOIs	https://doi.org/10.1016/S0021-9673(00)90100-6
State	Published - 1986

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abstract = "Gas chromatography with chemical ionization or electron impact mass spectrometry and selected ion monitoring provided a simple and sensitive method for measuring organophosphorus insecticides. Chemical ionization produced highermass ions which might increase the selectivity and sensitivity of the assay. The recovery of organophosphates from saline and urine was greater than 75%. The recovery of these compounds from plasma was less than the saline because of the binding of insecticides to plasma protein. Insecticides with lower LD50 values showed lower recovery from plasma than organophosphates with higher LD50 values.",

author = "Singh, {Ashok K.} and Hewetson, {David W.} and Jordon, {Kathryn C.} and Muhammed Ashraf",

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AU - Hewetson, David W.

AU - Jordon, Kathryn C.

AU - Ashraf, Muhammed

PY - 1986

Y1 - 1986

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AB - Gas chromatography with chemical ionization or electron impact mass spectrometry and selected ion monitoring provided a simple and sensitive method for measuring organophosphorus insecticides. Chemical ionization produced highermass ions which might increase the selectivity and sensitivity of the assay. The recovery of organophosphates from saline and urine was greater than 75%. The recovery of these compounds from plasma was less than the saline because of the binding of insecticides to plasma protein. Insecticides with lower LD50 values showed lower recovery from plasma than organophosphates with higher LD50 values.

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Analysis of organophosphorus insecticides in biological samples by selective ion monitoring gas chromatography-mass spectrometry

Abstract

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