Analysis of human urine for pyridine-N-oxide metabolites of 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen

Keyphrases

• Lung 100%
• Tobacco 100%
• Carcinogen 100%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 100%
• Pyridine N-oxide 100%
• Human Urine 100%
• N-oxides 100%
• N-methylmorpholine N-oxide 100%
• Smokers 41%
• Phenethyl Isothiocyanate (PEITC) 41%
• Creatinine 33%
• Rodents 25%
• Watercress 25%
• Pyridine N 25%
• N-oxidation 25%
• Metabolic Activation 16%
• Gluc 16%
• Oral Cancer 8%
• Lung Cancer 8%
• Metabolism 8%
• Primates 8%
• Cancer Etiology 8%
• Causal Factors 8%
• Urinary Biomarkers 8%
• Smokeless Tobacco Users 8%
• 1-Butanol 8%
• Smokeless Tobacco Products 8%
• Epidemiol 8%
• Pyridyl 8%
• Hydroxylation 8%
• High-performance Liquid Chromatography-electrospray Ionization-tandem Mass Spectrometry 8%
• Major Metabolites 8%
• Proteus Mirabilis 8%
• Carcinogenicity 8%
• Urinary Excretion 8%
• Metabolic Detoxification 8%
• Detoxification Pathways 8%
• Detoxification Products 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogen 100%
• NNK 100%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 100%
• Phenethyl Isothiocyanate 35%
• Creatinine 28%
• Watercress 21%
• Detoxication 21%
• Biological Marker 14%
• Chewing Tobacco 14%
• High Performance Liquid Chromatography 7%
• Malignant Neoplasm 7%
• Mouth Cancer 7%
• Lung Cancer 7%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanol 7%
• Proteus mirabilis 7%
• Carcinogenicity 7%
• Prey 7%
• Electrospray Ionization 7%
• Butanol 7%
• Glucuronic Acid 7%