Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography

Sheng Cao, José O. Maldonado, Iwen F. Grigsby, Louis M. Mansky, Wei Zhang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The particle structure of human T-cell leukemia virus type 1 (HTLV-1) is poorly characterized. Here, we have used cryo-electron tomography to analyze HTLV-1 particle morphology. Particles produced from MT-2 cells were polymorphic, roughly spherical, and varied in size. Capsid cores, when present, were typically poorly defined polyhedral structures with at least one curved region contacting the inner face of the viral membrane. Most of the particles observed lacked a defined capsid core, which likely impacts HTLV-1 particle infectivity.

Original languageEnglish (US)
Pages (from-to)2430-2435
Number of pages6
JournalJournal of virology
Volume89
Issue number4
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015, American Society for Microbiology.

Fingerprint

Dive into the research topics of 'Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography'. Together they form a unique fingerprint.

Cite this