Analysis of HIV tropism in Ugandan infants.

Jessica D. Church; Wei Huang; Anthony Mwatha; Philippa Musoke; J. Brooks Jackson; Danstan Bagenda; Saad B. Omer; Deborah Donnell; Clemensia Nakabiito; Chineta Eure; Laura A. Guay; Allan Taylor; Paul M. Bakaki; Flavia Matovu; Michelle McConnell; Mary Glenn Fowler; Susan H. Eshleman

Analysis of HIV tropism in Ugandan infants.

Jessica D. Church
, Wei Huang
, Anthony Mwatha
, Philippa Musoke
, J. Brooks Jackson
, Danstan Bagenda
, Saad B. Omer
, Deborah Donnell
, Clemensia Nakabiito
, Chineta Eure
, Laura A. Guay
, Allan Taylor
, Paul M. Bakaki
, Flavia Matovu
, Michelle McConnell
, Mary Glenn Fowler
, Susan H. Eshleman

Administration (TMED)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

Original language	English (US)
Pages (from-to)	498-503
Number of pages	6
Journal	Current HIV research
Volume	8
Issue number	7
State	Published - Oct 1 2010

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title = "Analysis of HIV tropism in Ugandan infants.",

abstract = "HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7\%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7\%) with subtype D, 3/57 (5.3 \%) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7\%) of 30 infants over 6-12 months. Six (85.7\%) of seven infants with DM HIV died, compared to 21/67 (31.3\%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).",

author = "Church, \{Jessica D.\} and Wei Huang and Anthony Mwatha and Philippa Musoke and Jackson, \{J. Brooks\} and Danstan Bagenda and Omer, \{Saad B.\} and Deborah Donnell and Clemensia Nakabiito and Chineta Eure and Guay, \{Laura A.\} and Allan Taylor and Bakaki, \{Paul M.\} and Flavia Matovu and Michelle McConnell and Fowler, \{Mary Glenn\} and Eshleman, \{Susan H.\}",

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AU - Huang, Wei

AU - Mwatha, Anthony

AU - Musoke, Philippa

AU - Jackson, J. Brooks

AU - Bagenda, Danstan

AU - Omer, Saad B.

AU - Donnell, Deborah

AU - Nakabiito, Clemensia

AU - Eure, Chineta

AU - Guay, Laura A.

AU - Taylor, Allan

AU - Bakaki, Paul M.

AU - Matovu, Flavia

AU - McConnell, Michelle

AU - Fowler, Mary Glenn

AU - Eshleman, Susan H.

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PY - 2010/10/1

Y1 - 2010/10/1

N2 - HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

AB - HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

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JO - Current HIV research

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IS - 7

ER -

Analysis of HIV tropism in Ugandan infants.

Abstract

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