Analysis of HIV tropism in Ugandan infants.

Jessica D. Church; Wei Huang; Anthony Mwatha; Philippa Musoke; J. Brooks Jackson; Danstan Bagenda; Saad B. Omer; Deborah Donnell; Clemensia Nakabiito; Chineta Eure; Laura A. Guay; Allan Taylor; Paul M. Bakaki; Flavia Matovu; Michelle McConnell; Mary Glenn Fowler; Susan H. Eshleman

Analysis of HIV tropism in Ugandan infants.

Jessica D. Church, Wei Huang, Anthony Mwatha, Philippa Musoke, J. Brooks Jackson, Danstan Bagenda, Saad B. Omer, Deborah Donnell, Clemensia Nakabiito, Chineta Eure, Laura A. Guay, Allan Taylor, Paul M. Bakaki, Flavia Matovu, Michelle McConnell, Mary Glenn Fowler, Susan H. Eshleman

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Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

Original language	English (US)
Pages (from-to)	498-503
Number of pages	6
Journal	Current HIV research
Volume	8
Issue number	7
State	Published - Oct 1 2010

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title = "Analysis of HIV tropism in Ugandan infants.",

abstract = "HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).",

author = "Church, {Jessica D.} and Wei Huang and Anthony Mwatha and Philippa Musoke and Jackson, {J. Brooks} and Danstan Bagenda and Omer, {Saad B.} and Deborah Donnell and Clemensia Nakabiito and Chineta Eure and Guay, {Laura A.} and Allan Taylor and Bakaki, {Paul M.} and Flavia Matovu and Michelle McConnell and Fowler, {Mary Glenn} and Eshleman, {Susan H.}",

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AU - Huang, Wei

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AU - Musoke, Philippa

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AU - Bagenda, Danstan

AU - Omer, Saad B.

AU - Donnell, Deborah

AU - Nakabiito, Clemensia

AU - Eure, Chineta

AU - Guay, Laura A.

AU - Taylor, Allan

AU - Bakaki, Paul M.

AU - Matovu, Flavia

AU - McConnell, Michelle

AU - Fowler, Mary Glenn

AU - Eshleman, Susan H.

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PY - 2010/10/1

Y1 - 2010/10/1

N2 - HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

AB - HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

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Analysis of HIV tropism in Ugandan infants.

Abstract

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