Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis

Jeffrey C. Edberg, Eduardo Wainstein, Jianming Wu, Elena Csernok, Michael C. Sneller, Gary S. Hoffman, Edward C. Keystone, Wolfgang L. Gross, Robert P. Kimberly

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Fcγ receptors (FcγRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcγR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcγR (FcγRIIa-H131/R131 and FcγRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalExperimental and Clinical Immunogenetics
Volume14
Issue number3
StatePublished - Jan 1998

Keywords

  • ANCA
  • Fcγ receptors
  • Monocyte/macrophages
  • Mononuclear phagocytes
  • Neutrophils
  • Vasculitis

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