TY - JOUR
T1 - Analysis of detomidine in horse blood, plasma and urine samples utilizing a sensitive gas chromatography-mass spectrometry method
AU - Singh, Ashok K.
AU - Mishra, Usha
AU - Ashraf, Muhammed
AU - Abdennebi, El Hassane
AU - Granley, Kae
AU - Dombrovskis, Dzintra
AU - Hewetson, Dave
AU - Stowe, Clarence M.
PY - 1987
Y1 - 1987
N2 - Chemical ionization- an electron impact ionization-selective ion monitoring provided a simple and sensitive method for measuring detomidine (Domosedan), a potent sedative-analgesic drug for horses and cattle. Chemical ionization was at least 10 times more sensitive than electron impact ionization. By using propranolol as an internal standard, we found that the recovery of detomidine from the extraction procedure used in this study was greater than 75% for plasma, whole blood, or urine samples. Approximately 68% of detomidine was bound to plasma protein and 53% was bound to red blood cells.
AB - Chemical ionization- an electron impact ionization-selective ion monitoring provided a simple and sensitive method for measuring detomidine (Domosedan), a potent sedative-analgesic drug for horses and cattle. Chemical ionization was at least 10 times more sensitive than electron impact ionization. By using propranolol as an internal standard, we found that the recovery of detomidine from the extraction procedure used in this study was greater than 75% for plasma, whole blood, or urine samples. Approximately 68% of detomidine was bound to plasma protein and 53% was bound to red blood cells.
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U2 - 10.1016/S0021-9673(01)86852-7
DO - 10.1016/S0021-9673(01)86852-7
M3 - Article
C2 - 3680434
AN - SCOPUS:0023212693
SN - 0021-9673
VL - 404
SP - 223
EP - 232
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - C
ER -