Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Lijuan L. Shang; Samuel C. Dudley; Arnold E. Pfahnl

Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Lijuan L. Shang
, Samuel C. Dudley
, Arnold E. Pfahnl

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

By directed differentiation using the hanging drop method, cardiomyocytes (CMs) can be derived from mouse embryonic stem cells. These spontaneously active CMs can then be isolated from the embryoid bodies and studied electrophysiologically for analysis of arrhythmic potential. This method is particularly advantangeous for studying CMs derived from genetically modified stem cells, in which mutations result in embryonic lethality.

Original language	English (US)
Pages (from-to)	221-231
Number of pages	11
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	330
State	Published - 2006

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title = "Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.",

abstract = "By directed differentiation using the hanging drop method, cardiomyocytes (CMs) can be derived from mouse embryonic stem cells. These spontaneously active CMs can then be isolated from the embryoid bodies and studied electrophysiologically for analysis of arrhythmic potential. This method is particularly advantangeous for studying CMs derived from genetically modified stem cells, in which mutations result in embryonic lethality.",

author = "Shang, \{Lijuan L.\} and Dudley, \{Samuel C.\} and Pfahnl, \{Arnold E.\}",

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language = "English (US)",

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journal = "Methods in molecular biology (Clifton, N.J.)",

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AU - Shang, Lijuan L.

AU - Dudley, Samuel C.

AU - Pfahnl, Arnold E.

PY - 2006

Y1 - 2006

N2 - By directed differentiation using the hanging drop method, cardiomyocytes (CMs) can be derived from mouse embryonic stem cells. These spontaneously active CMs can then be isolated from the embryoid bodies and studied electrophysiologically for analysis of arrhythmic potential. This method is particularly advantangeous for studying CMs derived from genetically modified stem cells, in which mutations result in embryonic lethality.

AB - By directed differentiation using the hanging drop method, cardiomyocytes (CMs) can be derived from mouse embryonic stem cells. These spontaneously active CMs can then be isolated from the embryoid bodies and studied electrophysiologically for analysis of arrhythmic potential. This method is particularly advantangeous for studying CMs derived from genetically modified stem cells, in which mutations result in embryonic lethality.

UR - https://www.scopus.com/pages/publications/33747438326

UR - https://www.scopus.com/pages/publications/33747438326#tab=citedBy

M3 - Article

C2 - 16846027

AN - SCOPUS:33747438326

SN - 1064-3745

VL - 330

SP - 221

EP - 231

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Abstract

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