Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Lijuan L. Shang, Samuel C. Dudley, Arnold E. Pfahnl

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


By directed differentiation using the hanging drop method, cardiomyocytes (CMs) can be derived from mouse embryonic stem cells. These spontaneously active CMs can then be isolated from the embryoid bodies and studied electrophysiologically for analysis of arrhythmic potential. This method is particularly advantangeous for studying CMs derived from genetically modified stem cells, in which mutations result in embryonic lethality.

Original languageEnglish (US)
Pages (from-to)221-231
Number of pages11
JournalMethods in molecular biology (Clifton, N.J.)
StatePublished - 2006


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