TY - JOUR
T1 - Analysis of a homologous series of perfluorocarboxylates from American Red Cross adult blood donors, 2000-2001 and 2006
AU - Olsen, Geary W.
AU - Ellefson, Mark E.
AU - Mair, David C.
AU - Church, Timothy R.
AU - Goldberg, Corinne L.
AU - Herron, Ross M.
AU - Medhdizadehkashi, Zahra
AU - Nobiletti, John B.
AU - Rios, Jorge A.
AU - Reagen, William K.
AU - Zobel, Larry R.
PY - 2011/10/1
Y1 - 2011/10/1
N2 - The purpose of this study was to determine the concentration trends of a nine-target-analyte homologous series of perfluorocarboxylates from six American Red Cross adult blood donor centers. A total of 645 serum and 600 plasma samples were obtained in 2000-2001 and 2006, respectively, with samples stratified for each 10-year (20-69) age- and sex-group per each location. Samples were extracted by protein precipitation and quantified by using tandem mass spectrometry. The nine perfluorocarboxylates were perfluorobutanoate (PFBA, C 3F 7CO 2 -), perfluoropentanoate (PFPeA, C 4F 9CO 2 -), perfluorohexanoate (PFHxA, C 5F 11CO 2 -), perfluoroheptanoate (PFHpA, C 6F 13CO 2 -), perfluorooctanoate (PFOA, C 7F 15CO 2 -), perfluorononanoate (PFNA, C 8F 17CO 2 -), perfluorodecanoate (PFDA, C 9F 19CO 2 -), perfluoroundecanoate (PFUnA,C 10F 21CO 2 -), and perfluorododecanoate (PFDoA, C 11F 23CO 2 -). The majority of measurements were less than the lower limit of quantitation for PFPeA, PFHxA, and PFDoA. For the remaining targeted analytes, the geometric mean serum and plasma concentrations (ng/mL) for 2000-2001 and 2006 were, respectively, as follows: PFBA 2.61 vs 0.33, PFHpA 0.13 vs 0.09, PFOA 4.70 vs 3.44, PFNA 0.57 vs 0.97, PFDA 0.16 vs 0.34, and PFUnA 0.10 vs 0.18. Estimates of the 95th percent tolerance limits (ng/mL) were as follows: PFBA 5.3 vs 1.4, PFHpA 0.4 vs 0.4, PFOA 12.3 vs 7.7, PFNA 1.4 vs 2.2, PFDA 0.4 vs 0.8, and PFUnA 0.3 vs 0.5. Important observations were the decline in PFBA and increase in PFNA, PFDA, and PFUnA concentrations between 2000-2001 and 2006. The longer chain length perfluorocarboxylates were also highly correlated with each other.
AB - The purpose of this study was to determine the concentration trends of a nine-target-analyte homologous series of perfluorocarboxylates from six American Red Cross adult blood donor centers. A total of 645 serum and 600 plasma samples were obtained in 2000-2001 and 2006, respectively, with samples stratified for each 10-year (20-69) age- and sex-group per each location. Samples were extracted by protein precipitation and quantified by using tandem mass spectrometry. The nine perfluorocarboxylates were perfluorobutanoate (PFBA, C 3F 7CO 2 -), perfluoropentanoate (PFPeA, C 4F 9CO 2 -), perfluorohexanoate (PFHxA, C 5F 11CO 2 -), perfluoroheptanoate (PFHpA, C 6F 13CO 2 -), perfluorooctanoate (PFOA, C 7F 15CO 2 -), perfluorononanoate (PFNA, C 8F 17CO 2 -), perfluorodecanoate (PFDA, C 9F 19CO 2 -), perfluoroundecanoate (PFUnA,C 10F 21CO 2 -), and perfluorododecanoate (PFDoA, C 11F 23CO 2 -). The majority of measurements were less than the lower limit of quantitation for PFPeA, PFHxA, and PFDoA. For the remaining targeted analytes, the geometric mean serum and plasma concentrations (ng/mL) for 2000-2001 and 2006 were, respectively, as follows: PFBA 2.61 vs 0.33, PFHpA 0.13 vs 0.09, PFOA 4.70 vs 3.44, PFNA 0.57 vs 0.97, PFDA 0.16 vs 0.34, and PFUnA 0.10 vs 0.18. Estimates of the 95th percent tolerance limits (ng/mL) were as follows: PFBA 5.3 vs 1.4, PFHpA 0.4 vs 0.4, PFOA 12.3 vs 7.7, PFNA 1.4 vs 2.2, PFDA 0.4 vs 0.8, and PFUnA 0.3 vs 0.5. Important observations were the decline in PFBA and increase in PFNA, PFDA, and PFUnA concentrations between 2000-2001 and 2006. The longer chain length perfluorocarboxylates were also highly correlated with each other.
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U2 - 10.1021/es1043535
DO - 10.1021/es1043535
M3 - Article
C2 - 21528903
AN - SCOPUS:80053401497
SN - 0013-936X
VL - 45
SP - 8022
EP - 8029
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 19
ER -