Analysis and antiproliferative activity of bark extractives of Betula neoalaskana and B. papyrifera. Synthesis of the most active extractive component - Betulin 3-caffeate

Igor V Kolomitsyn; Jon M Holy; Edward Perkins; Pavel A. Krasutsky

doi:10.1177/1934578x0700200105

Analysis and antiproliferative activity of bark extractives of Betula neoalaskana and B. papyrifera. Synthesis of the most active extractive component - Betulin 3-caffeate

Igor V Kolomitsyn, Jon M Holy, Edward Perkins, Pavel A. Krasutsky

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The chemical content of outer birch bark extractive from the North American birches Betula papyrifera Marshall (paper birch) and B. neoalaskana Sargent (Alaskan paper birch) has been evaluated by GC/MS, HPLC and NMR spectroscopy. The comparative antiproliferative activity of the extractive and major triterpenoid components was studied using a number of human and murine malignant (P19, N2/D1, K1735-M2, PC-3 and CaOV3) and normal (BJ) cell lines. Betulin 3-caffeate was found to exhibit the highest antiproliferative activity among all triterpenoid components, including betulinic acid. Synthesis of betulin 3-caffeate from betulin has been developed.

Original language	English (US)
Pages (from-to)	17-26
Number of pages	10
Journal	Natural Product Communications
Volume	2
Issue number	1
DOIs	https://doi.org/10.1177/1934578x0700200105
State	Published - 2007

Keywords

Antiproliferative
Betula neoalaskana
Betula papyrifera
Betulin
Betulin 3-caffeate
Betulinic acid
Birch bark
Lupeol
Oleanolic acid

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10.1177/1934578x0700200105

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title = "Analysis and antiproliferative activity of bark extractives of Betula neoalaskana and B. papyrifera. Synthesis of the most active extractive component - Betulin 3-caffeate",

abstract = "The chemical content of outer birch bark extractive from the North American birches Betula papyrifera Marshall (paper birch) and B. neoalaskana Sargent (Alaskan paper birch) has been evaluated by GC/MS, HPLC and NMR spectroscopy. The comparative antiproliferative activity of the extractive and major triterpenoid components was studied using a number of human and murine malignant (P19, N2/D1, K1735-M2, PC-3 and CaOV3) and normal (BJ) cell lines. Betulin 3-caffeate was found to exhibit the highest antiproliferative activity among all triterpenoid components, including betulinic acid. Synthesis of betulin 3-caffeate from betulin has been developed.",

keywords = "Antiproliferative, Betula neoalaskana, Betula papyrifera, Betulin, Betulin 3-caffeate, Betulinic acid, Birch bark, Lupeol, Oleanolic acid",

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AU - Kolomitsyn, Igor V

AU - Holy, Jon M

AU - Perkins, Edward

AU - Krasutsky, Pavel A.

PY - 2007

Y1 - 2007

N2 - The chemical content of outer birch bark extractive from the North American birches Betula papyrifera Marshall (paper birch) and B. neoalaskana Sargent (Alaskan paper birch) has been evaluated by GC/MS, HPLC and NMR spectroscopy. The comparative antiproliferative activity of the extractive and major triterpenoid components was studied using a number of human and murine malignant (P19, N2/D1, K1735-M2, PC-3 and CaOV3) and normal (BJ) cell lines. Betulin 3-caffeate was found to exhibit the highest antiproliferative activity among all triterpenoid components, including betulinic acid. Synthesis of betulin 3-caffeate from betulin has been developed.

AB - The chemical content of outer birch bark extractive from the North American birches Betula papyrifera Marshall (paper birch) and B. neoalaskana Sargent (Alaskan paper birch) has been evaluated by GC/MS, HPLC and NMR spectroscopy. The comparative antiproliferative activity of the extractive and major triterpenoid components was studied using a number of human and murine malignant (P19, N2/D1, K1735-M2, PC-3 and CaOV3) and normal (BJ) cell lines. Betulin 3-caffeate was found to exhibit the highest antiproliferative activity among all triterpenoid components, including betulinic acid. Synthesis of betulin 3-caffeate from betulin has been developed.

KW - Antiproliferative

KW - Betula neoalaskana

KW - Betula papyrifera

KW - Betulin

KW - Betulin 3-caffeate

KW - Betulinic acid

KW - Birch bark

KW - Lupeol

KW - Oleanolic acid

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JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

Analysis and antiproliferative activity of bark extractives of Betula neoalaskana and B. papyrifera. Synthesis of the most active extractive component - Betulin 3-caffeate

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