Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

Peter Grundt; Sarah Little Jane Husband; Robert R. Luedtke; Michelle Taylor; Amy Hauck Newman

doi:10.1016/j.bmcl.2006.10.076

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

Peter Grundt
, Sarah Little Jane Husband
, Robert R. Luedtke
, Michelle Taylor
, Amy Hauck Newman

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A series of analogues of the dopamine D2 receptor antagonist L741,626 were synthesized and evaluated for binding and function at D2 family receptor subtypes. Several analogues showed comparable binding profiles to the parent ligand, however, in general, chemical modification served to reduce D2 binding affinity and selectivity.

Original language	English (US)
Pages (from-to)	745-749
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2006.10.076
State	Published - Feb 1 2007

Bibliographical note

Funding Information:
The research reported herein was supported by funds from the NIDA Intramural Research Program and 1 DA 13584. P.G. was supported by a National Institutes of Health (NIH) Visiting Fellowship. S.L.J.H. was supported by a NIH summer IRTA fellowship.

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SDG 3 Good Health and Well-being

Keywords

Dopamine D2 receptor antagonists

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10.1016/j.bmcl.2006.10.076

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abstract = "A series of analogues of the dopamine D2 receptor antagonist L741,626 were synthesized and evaluated for binding and function at D2 family receptor subtypes. Several analogues showed comparable binding profiles to the parent ligand, however, in general, chemical modification served to reduce D2 binding affinity and selectivity.",

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note = "Funding Information: The research reported herein was supported by funds from the NIDA Intramural Research Program and 1 DA 13584. P.G. was supported by a National Institutes of Health (NIH) Visiting Fellowship. S.L.J.H. was supported by a NIH summer IRTA fellowship. ",

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AU - Luedtke, Robert R.

AU - Taylor, Michelle

AU - Newman, Amy Hauck

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ER -

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

Abstract

Bibliographical note

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