Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.