Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

S. Ognjanovic, Cindy K. Blair, Logan G. Spector, Leslie L. Robison, M. Roesler, Julie A. Ross

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.
Original languageEnglish (US)
JournalBritish Journal of Cancer
Volume104
DOIs
StatePublished - 2011

Keywords

  • epidemiology
  • analgesics
  • infants
  • leukaemia

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