Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

S. Ognjanovic; C. Blair; L. G. Spector; L. L. Robison; M. Roesler; J. A. Ross

doi:10.1038/sj.bjc.6606046

Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

S. Ognjanovic, C. Blair, L. G. Spector, L. L. Robison, M. Roesler, J. A. Ross

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Infant leukaemia is likely initiated in utero. Methods: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. Results: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. Conclusion: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

Original language	English (US)
Pages (from-to)	532-536
Number of pages	5
Journal	British Journal of Cancer
Volume	104
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjc.6606046
State	Published - Feb 1 2011

Bibliographical note

Funding Information:
This work was supported by NIH R01 CA79940, U10 CA13539, U10 CA98543, U1098413, the Children’s Cancer Research Fund, Minneapolis, MN, and NIH P30 CA77588 (University of Minnesota Masonic Cancer Center shared resource: Health Survey Research Center).

Keywords

analgesics
epidemiology
infants
leukaemia

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title = "Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study",

abstract = "Background: Infant leukaemia is likely initiated in utero. Methods: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. Results: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. Conclusion: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.",

keywords = "analgesics, epidemiology, infants, leukaemia",

author = "S. Ognjanovic and C. Blair and Spector, {L. G.} and Robison, {L. L.} and M. Roesler and Ross, {J. A.}",

note = "Funding Information: This work was supported by NIH R01 CA79940, U10 CA13539, U10 CA98543, U1098413, the Children{\textquoteright}s Cancer Research Fund, Minneapolis, MN, and NIH P30 CA77588 (University of Minnesota Masonic Cancer Center shared resource: Health Survey Research Center).",

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T1 - Analgesic use during pregnancy and risk of infant leukaemia

T2 - A Children's Oncology Group study

AU - Ognjanovic, S.

AU - Blair, C.

AU - Spector, L. G.

AU - Robison, L. L.

AU - Roesler, M.

AU - Ross, J. A.

N1 - Funding Information: This work was supported by NIH R01 CA79940, U10 CA13539, U10 CA98543, U1098413, the Children’s Cancer Research Fund, Minneapolis, MN, and NIH P30 CA77588 (University of Minnesota Masonic Cancer Center shared resource: Health Survey Research Center).

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Infant leukaemia is likely initiated in utero. Methods: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. Results: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. Conclusion: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

AB - Background: Infant leukaemia is likely initiated in utero. Methods: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression. Results: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy. Conclusion: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

KW - analgesics

KW - epidemiology

KW - infants

KW - leukaemia

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Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

Abstract

Bibliographical note

Keywords

UN SDGs

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