Analgesic effect of novel aralkyl-ketone piperazine derivatives YX0611-1 on chronic constriction injury of the sciatic nerve rats

Aim: To explore the anti-nociceptive effect of compound YX0611-1 in rats with a sciatic nerve chronic constriction injury (CCI). Methods: CCI model was performed as four ligatures placed around the fight sciatic nerve and tied without obstructing the blood supply of the nerve. Thermal withdrawal latency (TWL)and mechanical withdrawal threshold (MWT) of rats were determined by Hargreaves thermal radiation apparatus and electronic von Frey's method of microfilament, respectively. Results: YX0611-1 significantly reversed the reduction of mechanical and thermal hyperalgesia thresholds at doses of 80 mg·kg&bsup;-1&esup; and 160 mg·kg&bsup;-1&esup; after single gavage. Similar with the results of single gavage, the mechanical and thermal thresholds were also significantly enhanced at both doses after consecutive gavages, with the exception that YX0611-1 had no effect on mechanical threshold at 80 mg ·kg&bsup;-1&esup; Conclusion: In rat with neuropathic pain, compound YX0611-1 exerts analgesic effect.