TY - JOUR
T1 - Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer
T2 - A population-based case-control study
AU - Torti, Dorothea C.
AU - Christensen, Brock C.
AU - Storm, Craig A.
AU - Fortuny, Joan
AU - Perry, Ann E.
AU - Zens, Michael S.
AU - Stukel, Therese
AU - Spencer, Steven K.
AU - Nelson, Heather H.
AU - Karagas, Margaret R.
PY - 2011/8
Y1 - 2011/8
N2 - Background: Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially chemopreventive. Objective: We examined the relation between NSAID use and nonmelanoma skin cancer in a population-based case-control study. Methods: NSAID and analgesic use was analyzed in 1484 participants: 535 with squamous cell carcinoma (SCC), 487 with basal cell carcinoma (BCC), and 462 control subjects. Results: Use of NSAIDs, particularly aspirin, was associated with a reduced odds ratio (OR) of SCC, especially tumors positive for p53 (OR 0.29; 95% confidence interval 0.11-0.79) or with PTCH loss of heterozygosity (OR 0.35; 95% confidence interval 0.13-0.96). Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Risk of BCC was unrelated to NSAID use. Limitations: Self-reported drug use was a limitation. Conclusions: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.
AB - Background: Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially chemopreventive. Objective: We examined the relation between NSAID use and nonmelanoma skin cancer in a population-based case-control study. Methods: NSAID and analgesic use was analyzed in 1484 participants: 535 with squamous cell carcinoma (SCC), 487 with basal cell carcinoma (BCC), and 462 control subjects. Results: Use of NSAIDs, particularly aspirin, was associated with a reduced odds ratio (OR) of SCC, especially tumors positive for p53 (OR 0.29; 95% confidence interval 0.11-0.79) or with PTCH loss of heterozygosity (OR 0.35; 95% confidence interval 0.13-0.96). Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Risk of BCC was unrelated to NSAID use. Limitations: Self-reported drug use was a limitation. Conclusions: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.
KW - PTCH
KW - basal cell carcinoma
KW - case-control study
KW - nonmelanoma skin cancer
KW - nonsteroidal anti-inflammatory drug
KW - p53
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=79960390257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960390257&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2010.05.042
DO - 10.1016/j.jaad.2010.05.042
M3 - Article
C2 - 21529996
AN - SCOPUS:79960390257
SN - 0190-9622
VL - 65
SP - 304
EP - 312
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -
