An Unusual Base-Mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)aniline That Involves the Trifluoromethyl Group: An Expedient Route to 2-Arylquinolines

Lucjan Strekowski, Roman L. Wydra, Marek T. Cegla, Agnieszka Czarny, Donald B. Harden, Steven E. Patterson, Merle A. Battiste, James M. Coxon

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

: 6-(Substituted methylene)-N-(aryl-alkylidene)-2,4-cyclohexadien-l-imines, such as 13,17, and 21 (Scheme II) are suggested intermediates in a novel synthetic route to 2-arylquinolines based on the reaction of trifluoromethyl-substituted ketimines, such as la, with strong bases.

Original languageEnglish (US)
Pages (from-to)4777-4779
Number of pages3
JournalJournal of Organic Chemistry
Volume55
Issue number16
DOIs
StatePublished - 1990

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