An unprecedented dual responsive gelation of Carbopol induced by Pluronic P123 triblock copolymer

Parvaiz Ahmad Bhat; Oyais Ahmad Chat; Yongliang Zhang; Aijaz Ahmad Dar

doi:10.1016/j.polymer.2016.09.013

An unprecedented dual responsive gelation of Carbopol induced by Pluronic P123 triblock copolymer

Parvaiz Ahmad Bhat, Oyais Ahmad Chat, Yongliang Zhang, Aijaz Ahmad Dar

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We present a dynamic dual responsive biocompatible composite hydrogel based on Carbopol (CBP) and P123 in presence of salt. The P123 could induce gelation of Carbopol in otherwise nongelled 1% CBP (in presence of salt) even below its pKa which it is believed to make its delivery system viable in strongly acidic environment like gut. The gelation properties of the gel can be tuned in a desired manner by altering polymeric concentrations, pH and temperature in order to tailor the system for delivery applications. The hydrogel when investigated for Naproxen release shows no burst release of the drug, significant for efficient drug delivery system. Different kinetic models fitted to the release data revealed diffusion predominant release at pH 7.4 and relaxation predominant release at pH 4.

Original language	English (US)
Pages (from-to)	153-166
Number of pages	14
Journal	Polymer
Volume	102
DOIs	https://doi.org/10.1016/j.polymer.2016.09.013
State	Published - Oct 12 2016

Bibliographical note

Funding Information:
Bhat PA thanks Department of Higher Education, Government of J & K India for facilitating research under UGC-FDP Scheme. AAD acknowledges the Department of Science and Technology (DST), Govt. of India for providing funds under the FIST (Level-I, 2010–2014) scheme to the Department of Chemistry, University of Kashmir for procuring some of the equipment used for the study.

Publisher Copyright:
© 2016

Keywords

Carbopol
Gelation
Hydrogel
Naproxen
P123
Rheology

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10.1016/j.polymer.2016.09.013

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title = "An unprecedented dual responsive gelation of Carbopol induced by Pluronic P123 triblock copolymer",

abstract = "We present a dynamic dual responsive biocompatible composite hydrogel based on Carbopol (CBP) and P123 in presence of salt. The P123 could induce gelation of Carbopol in otherwise nongelled 1% CBP (in presence of salt) even below its pKa which it is believed to make its delivery system viable in strongly acidic environment like gut. The gelation properties of the gel can be tuned in a desired manner by altering polymeric concentrations, pH and temperature in order to tailor the system for delivery applications. The hydrogel when investigated for Naproxen release shows no burst release of the drug, significant for efficient drug delivery system. Different kinetic models fitted to the release data revealed diffusion predominant release at pH 7.4 and relaxation predominant release at pH 4.",

keywords = "Carbopol, Gelation, Hydrogel, Naproxen, P123, Rheology",

author = "Bhat, {Parvaiz Ahmad} and Chat, {Oyais Ahmad} and Yongliang Zhang and Dar, {Aijaz Ahmad}",

note = "Funding Information: Bhat PA thanks Department of Higher Education, Government of J & K India for facilitating research under UGC-FDP Scheme. AAD acknowledges the Department of Science and Technology (DST), Govt. of India for providing funds under the FIST (Level-I, 2010–2014) scheme to the Department of Chemistry, University of Kashmir for procuring some of the equipment used for the study. Publisher Copyright: {\textcopyright} 2016",

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doi = "10.1016/j.polymer.2016.09.013",

language = "English (US)",

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AU - Bhat, Parvaiz Ahmad

AU - Chat, Oyais Ahmad

AU - Zhang, Yongliang

AU - Dar, Aijaz Ahmad

N1 - Funding Information: Bhat PA thanks Department of Higher Education, Government of J & K India for facilitating research under UGC-FDP Scheme. AAD acknowledges the Department of Science and Technology (DST), Govt. of India for providing funds under the FIST (Level-I, 2010–2014) scheme to the Department of Chemistry, University of Kashmir for procuring some of the equipment used for the study. Publisher Copyright: © 2016

PY - 2016/10/12

Y1 - 2016/10/12

N2 - We present a dynamic dual responsive biocompatible composite hydrogel based on Carbopol (CBP) and P123 in presence of salt. The P123 could induce gelation of Carbopol in otherwise nongelled 1% CBP (in presence of salt) even below its pKa which it is believed to make its delivery system viable in strongly acidic environment like gut. The gelation properties of the gel can be tuned in a desired manner by altering polymeric concentrations, pH and temperature in order to tailor the system for delivery applications. The hydrogel when investigated for Naproxen release shows no burst release of the drug, significant for efficient drug delivery system. Different kinetic models fitted to the release data revealed diffusion predominant release at pH 7.4 and relaxation predominant release at pH 4.

AB - We present a dynamic dual responsive biocompatible composite hydrogel based on Carbopol (CBP) and P123 in presence of salt. The P123 could induce gelation of Carbopol in otherwise nongelled 1% CBP (in presence of salt) even below its pKa which it is believed to make its delivery system viable in strongly acidic environment like gut. The gelation properties of the gel can be tuned in a desired manner by altering polymeric concentrations, pH and temperature in order to tailor the system for delivery applications. The hydrogel when investigated for Naproxen release shows no burst release of the drug, significant for efficient drug delivery system. Different kinetic models fitted to the release data revealed diffusion predominant release at pH 7.4 and relaxation predominant release at pH 4.

KW - Carbopol

KW - Gelation

KW - Hydrogel

KW - Naproxen

KW - P123

KW - Rheology

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U2 - 10.1016/j.polymer.2016.09.013

DO - 10.1016/j.polymer.2016.09.013

M3 - Article

AN - SCOPUS:84987906177

SN - 0032-3861

VL - 102

SP - 153

EP - 166

JO - Polymer

JF - Polymer

ER -

An unprecedented dual responsive gelation of Carbopol induced by Pluronic P123 triblock copolymer

Abstract

Bibliographical note

Keywords

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