An overview of role of matrix components

D. M. Brown, A. S. Charonis, L. T. Furcht, D. J. Klein, S. M. Mauer, M. W. Steffes, P. E.C. Tsilibary

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The glomerular filtration barrier consists of complex matrix constituents interposed between the glomerular endothelial and epithelial cells, which constitute the lining of the glomerular capillaries. The matrix components include collagen and noncollagenous molecules such as laminin and proteoglycans. This review describes herein the metabolic consequences of diabetes mellitus to which increased permeability of the filtration barrier may be attributed by altering matrix molecules.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalDiabetes care
Issue number2
StatePublished - 1991


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