An overview of genetic factors influencing plasma lipid levels and coronary artery disease risk

I. Cetin Ozturk, Anthony A. Killeen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background. - Coronary artery disease (CAD) is a major cause of morbidity and mortality in most Western countries and its origin involves a significant genetic component. Methods. - Genetic and epidemiologic studies have been performed to identify factors that influence the CAD risk in the population. Results. - The primary loci that have been demonstrated to be associated with increased CAD risk owing to genetic mutations include the low-density lipoprotein receptor, apolipoprotein B-100, and lipoprotein(a). Additional implicated loci include lipoprotein lipase, apolipoprotein CII, cholesteryl ester transfer protein, apolipoprotein AI, and lecithin- cholesterol acyl transferase. Conclusions. - Numerous mutations in known genes exert a major effect on CAD risk in some patients. However, in most patients with CAD, the genetic component is believed to be attributable to the aggregate effect of loci that, individually, exert only a minor influence on lipoprotein revels.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume123
Issue number12
StatePublished - Dec 21 1999

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